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Authors' Submission Toolkit: A practical guide to getting.Categories of Articles . Note that word counts are exclusive of references, tables, and figure legends. Authors are advised that submissions not adhering to the guidelines provided below may be returned. NOTE: Special features in the Journal are invited by one of the Deputy Editors. If you are interested in contributing a special feature, please contact the Journal office (. Trials is an open access peer-reviewed medical journal covering performance and outcomes of randomized controlled trials. The journal is published by BioMed Central. Berkeley Electronic Press Selected Works. Reporting of interventions in randomised trials: An audit of journal instructions to authors. In addition, studies must be original, not confirmatory; must demonstrate a clear application to the current or future practice of medicine; must describe hypothesis testing, not hypothesis generation; must possess robust statistics; must be biologically based, not empiric; and must be important and interesting to our readership. Research articles can be submitted to one of the following four categories: Detailed guidelines are provided for each manuscript category and should be reviewed prior to submission. All Clinical Cancer Research articles should adhere to the following parameters: 1. Instructions to authors. Randomized controlled trials. It is a condition of publication in the Journal that authors grant an exclusive licence to. Journal Style; Clinical Trials; Reuse of Data Sets; Formatting Requirements. Clinical Trial Brief Reports. Submission to the Clinical Trial Brief Reports section is recommended for trials of novel agents, combinations, or indications that contain limited correlative science but report initial findings with an extraordinary degree of clinical activity, such as a high rate of complete radiographic responses.
At this time only clinical trials may be submitted in a Brief Report format; all other types of research should be submitted as a standard research article. Clinical Trial Brief Reports are eligible for expedited review based on the discretion of the Editors. Clinical Trial Brief Reports should adhere to the following parameters: 2. Cancer Therapy: Clinical. Clinical Cancer Research is interested in reports of clinical trials that involve both early and late stages of drug development. Clinical trial manuscripts should include a clear statement of the primary objective of the study, patient eligibility criteria, the measured endpoints, and the statistical approach and analysis (particularly for any biomarker hypotheses). Early (phase 0 or phase I) studies being considered for publication in Clinical Cancer Research should report on new compounds or new drug combinations. Studies that include pharmacokinetic assays, pharmacodynamic assays as a means to understand whether the target is modulated as expected, or investigation of individual differences in drug metabolism, toxicity, or responses (i. For clinical trials pertaining to immunotherapies, immune tests addressing the mechanism of action and potential biomarkers should be included. Clinical Cancer Research is also interested in first- in- man phase I trials of novel single agents or combinations of investigational or re- purposed agents that report initial observations resulting from perturbation of novel mechanisms of pathogenesis. In general the agent(s) studied and the mechanism(s) targeted should be justified by compelling pre- clinical data. Clinical Cancer Research will consider phase II trials that represent a possible advance in the treatment of cancer. Priority will be given to studies that include pharmacokinetic, pharmacodynamic, or pharmacogenetic endpoints. Reports of phase II trials should include a discussion of sample size calculations. Phase II trials that identify new active agents or regimens or that utilize novel biostatistical methods are also of interest. Clinical Cancer Research does not usually accept phase II trials that include few patients or are unlikely to be studied in phase III trials. Reports of randomized, controlled trials should follow CONSORT guidelines. In addition, PL 1. Title VIII, mandates the submission of . The law applies to trials that are not phase I or small device feasibility studies and that have at least one site in the United States. Basic results include summary data tables of baseline characteristics, participant flow, outcomes, and adverse events. There are no patient level data. See additional information on clinical trial registry in the General Instructions for Authors. Personalized Medicine and Imaging. Personalized Medicine. Clinical Cancer Research is interested in personalized medicine research describing biomarkers of therapeutic outcome or response. ![]() Predictive biomarker studies that estimate response or survival in advance of therapy or pharmacodynamic biomarker studies that are associated with target modulation are of particular interest. Highest priority will be given to those articles that are likely to have direct clinical applications and are definitive based on size of cohort, methodological approach, statistical analysis, multivariate analysis, reproducibility, and patient follow- up. Personalized medicine biomarker studies should have the following characteristics: They are definitive in size and statistical power. Prospective studies or prospective- retrospective studies will receive priority. Retrospective studies will be considered, but they should include verification using an independent cohort. They describe a unique cohort with results that directly impact clinical practice. Namely, there should be a clear clinical application that will have a significant impact on patient diagnosis or management. Studies focusing primarily on imaging methodology, in the absence of addressing a clinically relevant biological issue (e. Imaging studies should have the following characteristics: For new (or novel applications of established) imaging paradigms, confirmation using independent assays of efficacy is required. For new imaging paradigms addressing significant clinical issues (or preclinical studies that have the potential to address significant clinical issues) for which an established imaging paradigm exists, it is encouraged that the . Due to the overwhelming number of submissions in this Section of the Journal, guidelines are listed below to assist authors in their preparation of the manuscript. Flexibility will be maintained in the review process in regard to the availability of cell lines, model systems, tissues, and other resources for particular cancer types. Highest priority will be given to preclinical studies that involve new targets and/or are based on strong mechanism- based hypotheses. For compounds that constitute a new member of an already reported class (e. ![]() If available, multiple tumor cell lines must be presented to confirm the generality of the results. Confirmation using clinical tumor material is considered a strength. The in vivo confirmation of in vitro data is needed, including xenografts, patient- derived xenografts, orthotopic models, genetically engineered mice, tumor explants, syngeneic mouse hosts for immunological studies, veterinary animals, or other related information. In vivo experiments should have a measurable endpoint. Explanation should be provided as to why particular models were chosen. Pharmacodynamic analysis of in vivo samples to confirm target engagement following an intervention or other mechanistic hypotheses is strongly recommended. To the extent possible, analysis of an entire pathway rather than a single protein or gene is favored. For in vivo studies of radiation, fractionated doses will be favored over single- dose studies. For in vivo studies testing novel drugs, it is recommended to include a control arm with the standard of care in order to understand the magnitude of the benefit. For drugs in clinical use, pharmacokinetic data to correlate the observed therapeutic effect with clinically achievable concentrations would constitute a strength. Pharmacokinetic data for investigational compounds are encouraged. For rational combinations, statistical analysis of additive or synergistic effects is mandatory. Biology of Human Tumors. Manuscripts published in the Biology of Human Tumors Section will report novel findings with direct translational implications. Biological studies must be mechanistic, based on novel findings, and of eventual clinical importance. Use of at least two model systems, and in vivo data with clear endpoints, are needed. Authors should justify their selection of model systems. The human relevance of biological studies should be confirmed using human tumor data. Human tumor- based studies of biomarkers for molecular diagnosis or classification of cancer, or biomarkers predictive of metastasis, are also of interest. Tumor cohort studies should be definitive in size and statistical power, and confirmed using an independent cohort. In most cases, prognostic studies concerning the natural history of disease are not of interest. Manuscripts reporting data from human tumors must adhere to the REMARK criteria (http: //jnci. T1. expansion. html). Novelty will be a paramount gauge of relevance to this Section of the Journal. Manuscripts examining a previously published finding in a new cancer histology should be submitted elsewhere, as should be papers that are largely confirmatory with incremental new information. Novelty can be demonstrated both in topics of widespread interest and in new, previously unrecognized fields. Clinical/Translational relevance will constitute another important gauge of interest for publication in this Section of the Journal. The ability of the findings to inform or alter clinical practice can be immediate or in the foreseeable future. In general, Clinical Cancer Research is not interested in papers presenting the general molecular biology of cancer without obvious translational relevance; descriptive studies and purely in silico studies are discouraged. CCR Reviews. Concise treatments of timely subjects important to cancer researchers, Review Articles for Clinical Cancer Research are meant to stimulate consideration of new ideas and approaches and provide updates of new paradigms and innovative ideas for investigation. They need not present a comprehensive review of the literature. Brief reviews will receive priority. Authors of unsolicited Review Articles should first submit an outline of the proposed article for consideration by the Editors (. In 1. 98. 8 he became head of the newly formed Medical Statistics Laboratory (now Medical Statistics Group) at ICRF (now Cancer Research UK), and in 1. Centre for Statistics in Medicine in Oxford. In 1. 99. 7, Professor Altman received the Bradford Hill Medal for his contributions to medical statistics and a DSc from the University of London, and in 1. Professor of Statistics in Medicine by the University of Oxford. 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Derrick Rose 2016 player profile, game log, season stats, career stats, recent news If you play fantasy sports, get breaking news and immerse yourself in the ultimate. GameFly, the #1 video game rental service. Rent and buy PS4, PS3, PS Vita, PS2, PSP, Xbox One, Xbox 360, Xbox, GameCube, 3DS, DS, Wii U, Wii, GBA new or used video. Official game website, which includes trailers, screenshots and game information. Released in 2. 00. Final Fantasy series. The game introduced several innovations to the series: an open world split into zones, a seamless battle system, a controllable camera, a customizable . Final Fantasy XII also includes elements from previous games in the series such as summoned monsters, Chocobos, and Moogles. The game takes place in the fictional land of Ivalice, where the empires of Archadia and Rozarria are waging an endless war. Dalmasca, a small kingdom, is caught between the warring nations. When Dalmasca is annexed by Archadia, its princess, Ashe, creates a resistance movement. During the struggle, she meets Vaan, a young adventurer who dreams of becoming a sky pirate in command of an airship. They are quickly joined by a band of allies; together, they rally against the tyranny of the Archadian Empire. Final Fantasy XII received critical acclaim, earning numerous . Selling more than two million copies in Japan, it became the fourth best- selling Play. Station 2 game of 2. By November 2. 00. A sequel, Final Fantasy XII: Revenant Wings, was released for the Nintendo DS in 2. A high- definition remaster of the International Zodiac Job System version, subtitled The Zodiac Age, will be released worldwide for the Play. ![]() Station 4 in 2. 01. Gameplay. Unlike previous games in the series, the player can also control the camera with the right analog stick, allowing for a 3. The world of Final Fantasy XII is rendered to scale relative to the characters in it; instead of a caricature of the character roaming around miniature terrain, as found in the earlier Final Fantasy games, every area is represented proportionally. The player navigates the overworld on foot, Chocobo, or by airship. Blue lines depict the player's targets and red lines depict those of the enemies. Excluding the MMORPGFinal Fantasy XI, Final Fantasy XII is the first entry in the main Final Fantasy series not to include random encounters. Battles unfold in real time using the . Battles begin when the party comes within range of an aggressive enemy, the party attacks an enemy, or a story event initiates a confrontation. The player may switch any active character with an inactive character at any time, unless the active character is targeted by an attack or ability. Characters who are knocked out may also be substituted. A new feature in Final Fantasy XII is the . Each gambit consists of three parts: a target, an action, and a priority. The target specifies which ally or foe to act on and the condition for applying the action. For example, the target . The action is the command to be performed on the target. The priority determines which gambit to perform when multiple gambits are triggered. These heuristics guide the characters when acting autonomously, though player- directed commands are always given top priority. After defeating an Esper in combat, the player will be able to summon it to the battlefield. Unlike Final Fantasy X, however, Espers follow hidden gambits, rather than the player's direct command. The License Board is an array of panels that contain . Like the Sphere Grid in Final Fantasy X, all characters may obtain all licenses on the board; however, each Quickening and Esper license may only be activated by a single character. At this time, magicite, a magic- rich mineral, is commonly used in magic spells. The Rozarrian Empire makes its home in the vast inland plains of this continent as the eastern portion of it is largely desert and . Located in the middle of the Galtean Peninsula of Ordalia, Dalmasca is surrounded by an expanse of desert. The temperate climate of Dalmasca differs from the cold environs of Kerwon to the south and the lush plains of Valendia and Ordalia. Caught between the two powerful Empires, Dalmasca and a number of smaller nations have already been subjugated by Archadia two years before the game begins. Characters. Judge Magisters, upholders of Archadian law. The technological marvels of airships and synthetic nethicite. Rasler is killed in the war, the city of Nabudis is destroyed in a single explosion, and the Dalmascan king Raminas is assassinated moments after signing a treaty of surrender. Marquis Ondore announces that the assassin was Dalmascan captain Basch, who has been sentenced to death, and that Princess Ashe has committed suicide. In the treasury he finds a piece of magicite, a powerful magical crystal. He is discovered by Balthier and Fran, a pair of sky pirates looking for the magicite. The three escape as Dalmascan Resistance forces assault the palace, and in the sewers they meet the Resistance leader, Amalia, before being captured by Archadian forces. Detained in the Nalbina dungeons, they meet Basch, who was imprisoned but not killed, and who states his twin brother Gabranth was the one to kill the king. The four escape together with the help of Penelo, and flee to the floating city of Bhujerba. In Bhujerba, they meet Lamont, a curious boy who is Vayne's younger brother, Larsa, in disguise. On the Leviathan, the party is reunited with Amalia, who is revealed to be Princess Ashe. The party escapes the airship, but as Ashe had planned to use the magicite as proof that she was the princess. Convinced, Ashe and the group go to Mt. Bur- Omisace to seek the Gran Kiltias Anastasis, Ivalice's religious leader, and beg his approval of her as queen of Dalmasca. There they discover Doctor Cid, who created manufacted magicite, and who directs them to go to Giruvegan as it is the source of nethicite. They infiltrate the Bahamut, and find Larsa attempting to dissuade his brother Vayne from his plans for war. The gambit system was conceived early on as a way to facilitate this change. As for the license system, he explained that needing . Some of these included the ability for a second player to join in the gameplay, enabling a two- player mode. Another idea that was given a considerable amount of thought was the ability to recruit non- player characters to join in the mob hunts. Due to the technical limitations of the console and multiple number of characters joining the fray, the development phase took longer than expected, causing delays. Minaba mentions that the team tried to bring out Arabic culture in the design of the game. With the casting of actor Kouhei Takeda for the voice acting and motion capture, Vaan became less feminine and more . Yoshida feels this connection is sparked by the style of color used by both artists, which involves a color consistency between the characters and the environments. Scenario writer Daisuke Watanabe in turn fleshed out Shoda's plot into a script. Smith, who had previously worked on Vagrant Story and Final Fantasy X, acted as producer and translator. Each person was asked to show Square Enix three photos of his or her costume for a chance to win a trip to New York and participate in the Final Fantasy XII Gamer's Day event. The record states it took a total of five years, spanning from 2. Nobuo Uematsu, following his departure from Square Enix in 2. In addition to the theme song, violinist Taro Hakase co- composed, arranged, and performed the game's ending credits theme, Symphonic Poem . The former contains all the music used in the game's trailer performed by Taro Hakase, including Symphonic Poem . The drinks became commercially available in Japan on March 7, 2. Suntory also released a Final Fantasy XII Premium Box, which came with a Final Fantasy XII collector's card. The Potion was a limited edition product and is no longer available. Square Enix published the series in a total of five tank. The Battle Ultimania provides a description and analysis of the new battle system and its components, and developer interviews. On March 1. 6, 2. Final Fantasy XII became the sixth game to receive a perfect score from the Japanese gaming magazine Famitsu, making it the first Final Fantasy game and the first Play. Station 2 title to do so. It is also the second Yasumi Matsuno title to garner a perfect score, the first being Vagrant Story. The game was praised for its graphics, scenarios, game system, and the freshness it brought to the Final Fantasy series. The reviewer also criticized the sometimes tedious back and forth travel. On the other hand, Game. Spot took particular note of the . It also assuaged criticism that the gambit system would . However, it noted that, while . The player can control guest characters and summons and holding L1 doubles the game's running speed. The game also includes the western version's English voices and widescreen 1. DVD. It takes place one year after the events of Final Fantasy XII and follows the adventures of Vaan. Retrieved September 1, 2. Final Fantasy XII Collector's Edition Bonus DVD. Archived from the original on October 2. Retrieved 5 January 2. Final Fantasy XII North American instruction manual. Final Fantasy XII North American instruction manual. Final Fantasy XII North American instruction manual. Final Fantasy XII North American instruction manual. Final Fantasy XII Official Strategy Guide. Final Fantasy XII Official Strategy Guide. Final Fantasy XII Official Strategy Guide. Final Fantasy XII Official Strategy Guide. Final Fantasy XII Official Strategy Guide. Final Fantasy XII Official Strategy Guide. Final Fantasy XII Official Strategy Guide. Final Fantasy XII Official Strategy Guide. Final Fantasy XII North American instruction manual. Final Fantasy XII Official Strategy Guide. Final Fantasy XII Official Strategy Guide. Final Fantasy XII North American instruction manual. Square Enix (October 3. Square Enix (October 3. Square Enix (October 3. The vast plains in the interior are home to the great Rozarrian Empire. To the east of Rozarria, the land is arid and largely desert. Square Enix (October 3. Final Fantasy XII Scenario Ultimania (in Japanese). Final Fantasy XII Scenario Ultimania (in Japanese). Final Fantasy XII Official Strategy Guide. Final Fantasy XII Official Strategy Guide. Family Guy (TV Series 1. 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According to the European Court of Human Rights, Article 6 of the European Convention on Human Rights and the fair trial rights apply to all civil rights and obligations created under domestic law and therefore to all civil proceedings (see Apeh Uldozotteinek Szovetsege and Others v. If an individual's right under the law is at stake, the dispute must be determined through a fair process. The ACHPR has held that on the face of it military courts to do not satisfy civilians' right to a fair trial (see Constitutional Rights Project v. In this respect the ACHPR has reaffirmed the right to counsel as essential in guaranteeing a fair trial. The ACHPR held that individuals have the right to choose their own counsel and that giving the military tribunal the right to veto a counsel violates the right to a fair trial. The magistrate can be aided by the judicial and national police and can also, at the request of the prosecution and defence attorney, follow any number of leads regarding the case. The magistrate can also, when deemed appropriate, restrict the access the defence and prosecution have to the primary evidence and case information, which can include allowing witness statements to be introduced without the actual witness having to be in attendance. An extension of this power is the ability for the judge to declare, under special circumstances, the trial wholly or partially confidential. Suspects were simply imprisoned without trial, and tortured by the British army for information. This power was mostly used against the Catholic minority. The British government supplied deliberately misleading evidence to the European Court of Human Rights when it investigated this issue in 1. These convictions were later overturned, though an investigation into allegations that police officers perverted the course of justice failed to convict anyone of wrongdoing. The United Kingdom created an act . The judge has the power to clear the courtroom of the public and press, and the appellant if need be, if sensitive information must be relayed. The appellant is provided with a Special Advocate, who is appointed in order to represent their interests, however no contact can be made with the appellant after seeing the secret evidence. SIAC is mostly used for deportation cases, and other cases of public interest. Some argue that this undermines the British criminal justice system, as this evidence may not come under proper democratic scrutiny. Secret evidence can now be used in wide range of cases including deportations hearings, control orders proceedings, parole board cases, asset- freezing applications, pre- charge detention hearings in terrorism cases, employment tribunals and planning tribunals. Trials decided by jury, as they do not provide reasons for their decision, therefore do not allow for this. The court also implied a right to a reasoned verdict, irrespective of whether that was given by a judge or a jury. Under ECHR case law, jury decisions can also be problematic in circumstances where juries draw adverse inferences from trial judges' directions in contravention of Article 6(3) (b) and (c). In these countries, criminal courts are composed exclusively of judges. EU member states with a collaborative jury system which comprises a combination of jurors and judge include. The collaborative system, which can also be employed alongside the traditional jury model, is characterised by the professional judges and the jurors collectively determining all questions of law and fact, the issue of guilt and the sentence. Within the EU, the traditional jury system exists within Austria, Belgium, Ireland, Malta, Norway (only in serious appeal cases), Spain and the United Kingdom (England, Wales, Scotland and Northern Ireland). With the expansion of the EU, It is seen. Juveniles need to be competent to stand trial and be able to comprehend the proceedings for their criminal trial to be considered a fair trial. This stands as a contentious issue because many argue that it may never be fair for children to have a role in trial or be involved in criminal justice proceedings due to their age, inability to grasp legal concepts etc. In Sweden, children under the age of 1. Young people aged between 1. This care can often be in combination with fines or additional community service. For the most serious crimes, such as murder and manslaughter, the penalty may be institutionalisation at a specialised youth home. The National Board of Institutional Care is responsible to enforce these sentences. This punishment is for a fixed term, and its focus is on care, treatment and the rehabilitation of young offenders. By contrast, the age of criminal responsibility in the Netherlands is 1. A specialised youth police and courts system was reintroduced in the Netherlands, in order to provide for a specialised task force to deal with youth crime. At the age of 1. 6, an offender who commits crime may be tried in an adult court. Younger children under the age of 1. Older children (over the age of 1. In Sweden, the court system for children is not tailored towards their individual needs, rather the framework of the juvenile court system is based on the adult court system. However, in Sweden, unlike in the Netherlands, the mitigating circumstance of youth applies in order to provide for a young offender. Fair Trial, Right to, International Protection, Max Planck Encyclopedia of Public International Law^ abcdefghij. Doebbler, Curtis (2. Introduction to International Human Rights Law. ISBN 9. 78- 0- 9. The Universal Declaration of Human Rights: a common standard of achievement. Martinus Nijhoff Publishers. ISBN 9. 78- 9. 0- 4. Introduction to International Human Rights Law. ISBN 9. 78- 0- 9. The Universal Declaration of Human Rights: a common standard of achievement. Martinus Nijhoff Publishers. ISBN 9. 78- 9. 0- 4. Office of the United Nations High Commissioner for Human Rights. Introduction to International Human Rights Law. ISBN 9. 78- 0- 9. Introduction to International Human Rights Law. ISBN 9. 78- 0- 9. Diritto& Giustizia edizione online. Introduction to International Human Rights Law. ISBN 9. 78- 0- 9. Retrieved 2. 0 September 2. Retrieved 2. 0 September 2. The right to a fair trial and its multiple manifestations. Gerards (Eds.), Shaping Rights in the ECHR: The Role of the European Court of Human Rights in Determining the Scope of Human Rights (pp. Cambridge Books Online: Cambridge University Press.^. Retrieved 2. 0 September 2. Retrieved 2. 0 September 2. Chicago: University of Chicago Press, 2. Retrieved 2. 0 September 2. Retrieved 2. 0 September 2. Retrieved 2. 0 September 2. What is a merit hearing? During a merits hearing, a trial attorney from the Department of Homeland Security tests the applicant's credibility and the credibility of witnesses on behalf of the applicant. The trial attorney's job is to argue that the applicant should be removed from the country. Applicants provide testimony and required documents when seeking asylum through a merits hearing and must meet the previous and current orders of the immigration judge. Learn more about Law. |
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