Placebo response and antidepressant clinical trial outcome. To evaluate this, 5. FDA were examined to correlate placebo response magnitude with trial outcome. The magnitude of symptom reduction, percentage mean change from baseline in the Hamilton Depression Rating Scale (HAM- D), was assessed for patients assigned to placebo or an antidepressant. Correlation coefficients between symptom reduction with placebo and antidepressants and between symptom reduction with placebo and magnitude of advantage of antidepressants over placebo were assessed. A statistically significant positive correlation was seen between placebo and antidepressant response magnitude (r =. Only 2. 1. 1% of antidepressant treatment arms in trials with high placebo response (> 3. Response magnitude varies and has an important effect on antidepressant clinical trials, illustrating the need for a placebo arm to determine if the trial was sensitive to treatment differences and highlighting the dangers of cross- study comparisons. ![]() ![]() Placebos and Antidepressants. Severity of depressive symptoms and response to antidepressants and placebo in antidepressant trials Arif Khan a,b,*, Amy E. Brodhead a, Russell L. Antidepressants compared with placebos for. Antidepressants versus placebo for. Placebo response and antidepressant clinical trial. ![]()
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September 2017
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